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Empire Genomics prides itself in being a pioneer in the field of genomics and provides the clinical and research community with the key tools they need to advance scientific discovery. Our team of expert scientists affords us the ability to provide high quality and differentiated products & services to our customers.

Company Overview

Empire Genomics Corporate OfficeEmpire Genomics was created in 2006 from research started at the prestigious Roswell Park Cancer Institute in Buffalo, New York. The laboratory has a strong track record in the development of high throughput technologies to enable genome-wide analyses aimed at determining the underlying mechanisms for diseases.

Learn more about our history and vision
 
Landmark Publications
Integration of the cytogenetic landmarks into the draft sequence of the human genome
Nature Genetics.409:953-958, 2001

A Physical Map of the Human Genome Suitable for Systematic Sequencing
Nature Genetics. 409: 934-941, 2001

Initial sequencing and analysis of the human genome
Nature Genetics 409:860-921, 2001

Assembly of microrrays for genome-wide measurement of DNA Copy number
Nature Genetics. 29:263-264, 2001

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Nature Genetics 425:917-925, 2003

Complex patterns of copy number variation at sites of segmental duplications: an important category of structural variation in the human genome
The American Journal of Human Genetics. 120(2):270-284, 2006

Novel submicroscopic chromosomal abnormalities detected in Autism spectrum disorder
Biological Psychiatry. 63(12):1111-1117, 2008

Y-mediated unequal recombination interrupts CNTN4 in 3 subjects with Autism spectrum disorder
Journal of Medical Genetics. 2008 Mar 18

Challenges in array CGH for the analysis of cancer samples
Genetics in Medicine. 9(9):585-595, 2007

Recurrent 16p11.2 microdeletions in Autism
Human Molecular Genetics 17(4):628-638, 2008
 
About the Founder

Empire Genomics Founder Dr. Norma NowakDr. Norma Jean Nowak, Ph.D., is a recognized leader in the field of genomics. She currently serves as Chief Scientific Officer of Empire Genomics.

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Cancer
Challenges in array CGH for the analysis of cancer samples
Genetics in Medicine. 9(9):585-595, 2007

Chromosome 11 genomic changes in parathyroid adenoma and hyperplasia:  Array CGH, FISH and tissue microarrays
Genes Chromosomes Cancer. 47(8): 639-648, 2008

Array comparative genomic hybridization analysis of primary endometrial and ovarian high-grade neuroendocrine carcinoma associated with adenocarcinoma:  mystery resolved?
International Journal of Gynecological Pathology. 4:539-546, 2008

A comparative analysis of two tissue procurement approaches for the genomic profiling of clinical colorectal cancer samples
International Journal of Colorectal Disease. Published online  2008 Jul 16

The use of Array-Comparative Genomic Hybridization (a-CGH) to distinguish metastatic from primary synchronous carcinomas of the ovary and the uterus
Histopathology. 2008 Jul 16

A Role for Gab2 in Melanoma Metastasis
American Journal of Pathology. 2009 Apr; 174(4):1524-33

Uniparentalism in sporadic colorectal cancer is independent of imprint status, and coordinate for chromosomes 14 and 18
Cancer Genetics and Cytogenetics. 2009 Mar; 189(2):77-86

Translocation (4; 11) (p12; q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia
Cancer Genetics Cytogenetics. 177(2):143-146, 2007.

aCGH local number aberrations associated with overall copy number genomic instability in colorectal cancer: coordinate involvement of the regions inclcuding BCR and ABL
Mutation Research. 615(1-2): 1-11, 2007

Comparative genomic instabilities of thyroid and colon cancers
Stoler, D.L., Nowak, N.J., Matsui, S-I., Wiseman, S.M., Chen, N., Dutt, S., Bartos, J.D., Loree, T.R., Rigual, N.R., Hicks, W.L., Sait, S.N., Anderson, G.R.. Arch Otolaryngol Head Neck Surg 133(5):457-463, 2007

Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol
Chung, I., Karpf, A.R., Muindi, J.R., Conroy, J.M., Nowak, N.J., Johnson, C.S., Trump, D.L  J Biol Chem. 282(12):8704-8714, 2007

Loss of BRMS1 protein expression predicts reduced disease-free survival in hormone receptor negative and HER2 positive subsets of breast cancer
Hicks, D.G., Yoder, B.J., Short, S.,  Tarr, S., Prescott, N., Crowe, J.P.,  Dawson1, A.E., Budd, G.T., Sizemore, S., Cicek, M., Choueiri3, T., Tubbs, R.R., Gaile, D., Nowak, N., Accavitti-Loper, M.A., Frost, A.R., Welch6, D. R., and Casey, G.  . Clin Cancer Res  12:(22):6702-6708, 2006

Genomic profiles of colorectal cancers differ based on patient smoking status
Swede, H., Bartos, J. , Chen, N., Shaukat,  A.,  Dutt, S., McQuaid,  D., Natarajan, N. , Rodriguez-Bigas, M., Nowak, N., Wiseman, S., Alrawi, S., Brenner, B., Petrelli, N., Cummings, K.M., Stoler, D.L., Anderson, G.R.
Cancer Genet Cytogenet168(2):98-104, 2006

20q11.1 amplification in giant-cell tumor of bone: Array CGH, FISH, and association with outcome
Smith, L.T., Mayerson, J., Nowak, N.J., Suster, D., Mohammed, N., Long, S., Auer, H., Jones, S., McKeegan, C., Young, G., Bos, G., Plass, C., Morrison, C. Genes Chromosomes Cancer ;45(10):957-966, 2006

Genomic instability of human aberrant crypt foci measured by inter-(simple sequence repeat) pcr and array-cgh
Alrawi, S.J., Carroll, R.E., Hill, H.C., Gibbs, J.F., Tan, D., Brenner, B.M., Nowak, N.J., Swede, H., Stoler. D.L., Anderson, G.R. Mutat Res 10;601(1-2):30-38, 2006

Array CGH analysis of pediatric medulloblastomas
Rossi, M.R., Conroy, J., McQuaid, D., Nowak, N.J., Rutka, J.T., Cowell, J.K.Genes Chromosomes Cancer 45(3):290-303, 2006

Microarray data mining for potential selenium targets in chemoprevention of prostate cancer
Zhang, H., Dong, Y., Zhao, H., Brooks, J.D., Hawthorn, L., Nowak, N., Marshall, J.R., Gao, A.C., Ip. C. Cancer Genomics Proteomic. 2:97-114, 2005

Molecular characterization of a  consistent 4.5 megabase deletion in 4q28 in prostate cancer cells
Matsui, S.I., LaDuca, J., Rossi, M.R., Nowak, N.J., Cowell, J.K Cancer Genet Cytogenet 159:18-26, 2005

Characterization of the 1p/19q chromosomal loss in oligodendrogliomas using CGHa
Cowell, J.K., Barnett, G., Nowak, N.J.J Neuropathol Exper Neurol 63:2:151-158, 2004

Application of bacterial artificial chromosome array-based comparative genomic hybridization and spectral karotyping to the analysis of glioblastoma multiforme
Cowell, J.K., Matsui, S.I., Wang Y.D., LaDuca, J., Conroy, J., McQuaid, D., Nowak, N.J.  Cancer Genet  Cytogenet 151:1:36-51, 2004

Identification of differentially expressed genes in clinically distinct groups of serous ovarian carcinomas using cDNA microarray
Collins, Y., Tan, D.F., Pejovic, T., Mor, G., Qian, F., Rutherford, T., Varma, R., McQuaid D., Driscoll, D., Jiang, M., Deeb, G., Lele, S., Nowak, N., Odunsi, K.  Int J Mol Med 14:1:43-53, 2004

Molecular characterization of a consistent 4.5 megabase deletion in 4q28 in prostate cancer cells
Matsui, S.I., LaDuca, J., Rossi, M.R., Nowak, N.J., Cowell, J.K. Cancer Genet Cytogenet 159:18-26, 2005

Molecular characterization of the t(3;9) translocation associated with immortalization in the MCF10A cell line
Cowell, J.K., LaDuca, J., Rossi, M.R., Burkhardt, T., Nowak, N.J., Matsui, S-I. Cancer Genet Cytogenet 163:223-29, 2005

Two functional coding single   nucleotide polymorphisms in STK15 (Aurora-A) coordinately increase esophageal cancer risk
Kimura, M.T., Mori, T., Conroy, J., Nowak, N.J., Satomi, S., Katsuyuki, T., Nagase, H.  Cancer Res 65:3548-3554, 2005

In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells
Minderman, H., Conroy, J., O’Loughlin, K.L., McQuaid, D., Quinn, P., Li, S., Pendyala L., Nowak, N., Baer, M.R.  .  Mol Cancer Ther 4:885-900, 2005
Cowell, J,K.  

Identification of consistent novel megabase deletions in low-grade oligodendrogliomas using array-based comparative genomic hybridization
Rossi, M.R., Gaile, D., LaDuca, J., Matsui, S.I., Conroy, J., McQuaid, D., Chervinsky, D., Eddy, R., Chen, H-S., Barnett, G., Nowak, N.J., Genes Chromosomes Cancer, 44:85-96, 2005

Genome wide aberrations in pancreatic adenocarcinoma
Nowak, N.J., Gaile, D., Conroy, J.M., McQuaid, D., Cowell, J., Carter, R., Goggins, M.G., Hruban, R.H., Maitra, Cancer Genet Cytogene 161:36-50, 2005

Array comparative genomic hybridisation (aCGH) analysis of premenopausal breast cancers from a nuclear fallout area and matched cases from Western New York
Varma, G., Varma, R., Huang, H., Pryshchepava, A., Groth, J., Fleming, D., Nowak, N.J., McQuaid, D., Conroy, J., Mahoney, M., Moysich, K., Falkner, K.L., Geradts, J.  . Br J Cancer 93(6):699-708, 2005

Novel amplicons on the short arm of chromosome 7 identified using high resolution array CGH contain over expressed genes in addition to EGFR in glioblastoma multiforme.
Rossi, M.R., La Duca, J., Matsui, S., Nowak, N,J,, Hawthorn, L., Cowell, J.K.  Genes Chromosomes Cancer 44(4):392-404, 2005.

Genomic profiling of myeloid sarcoma by array comparative genomic hybridization
Deeb, G., Baer, M.R., Gaile, D.P., Sait, S.N., Barcos, M., Wetzler, M., Conroy, J.M., Nowak, N.J., Cowell, J.K., Cheney, R.T.  . Genes Chromosomes Cancer 44(4):373-383, 2005

Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability
Ionov, Y., Nowak, N., Perucho, M., Markowitz, S., Cowell, J.K.  .  Oncogene 23:639-645, 2004

Molecular analysis of region t(5;6) (q21;q21 in Wilms tumor
Bruce, C.K., Howard P., Nowak, N.J., Hoban, P.R.  .  Cancer Genet Cytogenet 141(2):106-113, 2003

Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors
Hackett, C., Hodgson, G., Law, M., Fridlyand, J., Osoegawa, K., De Jong, P., Nowak, N.J., Pinkel, D., Albertson, D., Jain, A., Jenkins, R, Gray, J., Weiss, W. Cancer Res 63:5266-5273, 2003

The pericentromeric region of human chromosome 11: evidence for a chromosome specific duplication.
Zhang, J., Qin, S., Sait, S.N.J., Haey, L.L., Henry, W.M., Gerhard, D.S., Higgins, M.J., Nowak, N.J., Shows, T.B. Cytogenet Cell Genet 94:137-141, 2001

Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: Identification of new amplification regions by fluorescence in situ hybridization and spectral karotyping.
Sait, S., Qadir, M., Conroy, J., Matsui, S., Nowak, N. J., Baer, M. Genes Chromosomes Cancer 34:1:42-47, 2002

Intrachromosomal genomic instability in human sporadic colorectal cancer measured by genome-wide allelotyping and inter(simple sequence repeat) PCR
Anderson, G., Brenner, B.M., Swede, H., Henry, W.M., Conroy, J.M., Karpenko, M.J., Issa, J.P., Bartos, J., Brunelle, J.K., Chen, N., Jahreis, G.P., Kahlenberg, M.S., Basik, M., Sait, S., Rodriguez-Bigas, M.A., Nowak, N.J., Petrelli, N.J., Shows, T.B., Stoler, D.L.. Cancer Res 61:8274-8283, 2001

Genome scanning with array CGH delineates regional alterations in murine islet carcinomas
Hodgson, G., Hager, J.H., Volik, S., Hariono, S., Wernick, M., Moore, D., Nowak, N., Albertson, A.G., Pinkel, D., Collins, C., Hanahan, D., Gray, J.W. Nat Genet 29: 459-464, 2001
 
Management Team

Empire Genomics Management TeamOur management team is comprised of highly experienced individuals with both extensive science and business acumen.

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Developmental Disorders
Recurrent 16p11.2 Microdeletions in Autism
Human Molecular Genetics. 17(4):628-638, 2008

A large interstitial deletion del(17)(p11.2p13.1) in a patient with Smith–Magenis Syndrome and Moyamoya Disease in a Patient With del(17)(p11.2p13.1)
American Journal of Medical Genetics. .  143(9):999-1008, 2007

Familial 4.3Mb duplication of 21q22 sheds new light on the Down syndrome Critical Region
Journal of Medical Genetics. 44(7):448-451, 2007

Disruption of Contactin 4 in 3 Subjects with Autism Spectrum Disorder
Journal of Medical Genetics. 18 Mar 2008.

Analytical and clinical validity of whole-genome oligonucleotide array comparative genomic hybridization for pediatric patients with mental retardation and developmental delay
American Journal of Medical Genetics. 2008

S.H.17p11.2p12 triplication and del(17)q11.2q12 in a severely affected child with dup(17)p11.2p12 syndrome
Clinical Genetics 72(1):47-58, 2007

Duplication of the entire 22.9-Mb human chromosome 21 syntenic region on mouse.chromosome16 causes cardiovascular and gastrointestinal abnormalities
Human Molecular Genetics  16(11):1359-1366, 2007

Novel karyotypic changes detected by comparative genomic hybridization in a case of congenital cervical immature teratoma
Birth Defects Res A Clin Mol Teratol 73(8):572-576, 2005

Rapid array-based genomic characterization of a subtle structural abnormality: a patient with psychosis and der(18)t(5;18)(p14.1;p11.23)
American Journal of Medical Genetics 134(3):282-289, 2005

Identification and characterization of constitutional chromosome abnormalities using arrays of bacterial artificial chromosomes
Brit J Cancer 90:4-860-865, 2004
 
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