Coexistence of t(2;14;11)(p16.1;q32;q23) and t(14;19)(q32;q13.3) chromosome tran...

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Coexistence of t(2;14;11)(p16.1;q32;q23) and t(14;19)(q32;q13.3) chromosome translocations in a patient with chronic lymphocytic leukemia: A case report

Medicine: December 2017 - Volume 96 - Issue 51 - p e9169; doi: 10.1097/MD.0000000000009169

Liu, Guangming MD; Wen, Zhongmei MD, PhDb; Lu, Xianglan MDc; Kim, Young Mi PhD; Wang, Xianfu MD; Crew, Rebecca M. BS; Cherry, Mohamad A. MD; Li, Shibo MD; Liu, Yuanyuan MD, PhD


Rationale: With combination of multiple techniques, we have successfully characterized unique, complex chromosomal changes in a patient with chronic lymphocytic leukemia (CLL), a lymphoproliferative disorder.

Diagnoses: The diagnosis was based on white blood cell, flow cytometry, and immunophenotypes and confirmed by karyotype, fluorescence in situ hybridization, and array comparative genomic hybridization from the patient's blood culture.

Interventions: The patient was given fludarabine, cyclophosphamide and rituximab (FCR) for 6 cycles.

Outcomes: After completion of 6 cycles of FCR, the computed tomography scans of the neck/chest/abdomen/pelvic showed that the patient in CR. During the 10-month follow-up, the patient's clinical course remained uneventful.

Lessons: The translocation t(14;19) identified in this patient is a recurrent translocation found in patients with chronic B-cell lymphoproliferative disorders and the 3-way translocation involving chromosomes 2, 14, and 11 may play a role as an enhancer.

Empire Genomic's BCL3 FISH probe was used in this publication.

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