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AARS-COG4 Fusion FISH Probe

The AARS-COG4 Fusion FISH Probe is used to confirm a fusion of the AARS and COG4 genes. The fusion of the AARS and COG4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
AARS-COG4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
AARS-COG4-20-RERE 20 (40 μL) 200 μL
AARS-COG4-20-REOR 20 (40 μL) 200 μL
AARS-COG4-20-REGO 20 (40 μL) 200 μL
AARS-COG4-20-REGR 20 (40 μL) 200 μL
AARS-COG4-20-REAQ 20 (40 μL) 200 μL
AARS-COG4-20-ORRE 20 (40 μL) 200 μL
AARS-COG4-20-OROR 20 (40 μL) 200 μL
AARS-COG4-20-ORGO 20 (40 μL) 200 μL
AARS-COG4-20-ORAQ 20 (40 μL) 200 μL
AARS-COG4-20-GORE 20 (40 μL) 200 μL
AARS-COG4-20-GOOR 20 (40 μL) 200 μL
AARS-COG4-20-GOGO 20 (40 μL) 200 μL
AARS-COG4-20-GOGR 20 (40 μL) 200 μL
AARS-COG4-20-GOAQ 20 (40 μL) 200 μL
AARS-COG4-20-GRRE 20 (40 μL) 200 μL
AARS-COG4-20-GROR 20 (40 μL) 200 μL
AARS-COG4-20-GRGO 20 (40 μL) 200 μL
AARS-COG4-20-GRGR 20 (40 μL) 200 μL
AARS-COG4-20-GRAQ 20 (40 μL) 200 μL
AARS-COG4-20-AQRE 20 (40 μL) 200 μL
AARS-COG4-20-AQOR 20 (40 μL) 200 μL
AARS-COG4-20-AQGO 20 (40 μL) 200 μL
AARS-COG4-20-AQGR 20 (40 μL) 200 μL
AARS-COG4-20-AQAQ 20 (40 μL) 200 μL

AARS Gene Summary

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]

Gene Name: Alanyl-tRNA Synthetase

Chromosome: CHR16: 70286296 -70323412

Locus: 16q22.1

COG4 Gene Summary

The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]

Gene Name: Component Of Oligomeric Golgi Complex 4

Chromosome: CHR16: 70514471 -70557457

Locus: 16q22.1

Gene Diseases

The AARS COG4 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.