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ABCC4-PTPN4 Fusion FISH Probe

The ABCC4-PTPN4 Fusion FISH Probe is used to confirm a fusion of the ABCC4 and PTPN4 genes. The fusion of the ABCC4 and PTPN4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ABCC4-PTPN4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ABCC4-PTPN4-20-RERE 20 (40 μL) 200 μL
ABCC4-PTPN4-20-REOR 20 (40 μL) 200 μL
ABCC4-PTPN4-20-REGO 20 (40 μL) 200 μL
ABCC4-PTPN4-20-REGR 20 (40 μL) 200 μL
ABCC4-PTPN4-20-REAQ 20 (40 μL) 200 μL
ABCC4-PTPN4-20-ORRE 20 (40 μL) 200 μL
ABCC4-PTPN4-20-OROR 20 (40 μL) 200 μL
ABCC4-PTPN4-20-ORGO 20 (40 μL) 200 μL
ABCC4-PTPN4-20-ORAQ 20 (40 μL) 200 μL
ABCC4-PTPN4-20-GORE 20 (40 μL) 200 μL
ABCC4-PTPN4-20-GOOR 20 (40 μL) 200 μL
ABCC4-PTPN4-20-GOGO 20 (40 μL) 200 μL
ABCC4-PTPN4-20-GOGR 20 (40 μL) 200 μL
ABCC4-PTPN4-20-GOAQ 20 (40 μL) 200 μL
ABCC4-PTPN4-20-GRRE 20 (40 μL) 200 μL
ABCC4-PTPN4-20-GROR 20 (40 μL) 200 μL
ABCC4-PTPN4-20-GRGO 20 (40 μL) 200 μL
ABCC4-PTPN4-20-GRGR 20 (40 μL) 200 μL
ABCC4-PTPN4-20-GRAQ 20 (40 μL) 200 μL
ABCC4-PTPN4-20-AQRE 20 (40 μL) 200 μL
ABCC4-PTPN4-20-AQOR 20 (40 μL) 200 μL
ABCC4-PTPN4-20-AQGO 20 (40 μL) 200 μL
ABCC4-PTPN4-20-AQGR 20 (40 μL) 200 μL
ABCC4-PTPN4-20-AQAQ 20 (40 μL) 200 μL

PTPN4 Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]

Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 4

Chromosome: CHR2: 120517206 -120735037

Locus: 2q14.2

ABCC4 Gene Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Gene Name: ATP Binding Cassette Subfamily C Member 4

Chromosome: CHR13: 95672082 -95953687

Locus: 13q32.1

Gene Diseases

The ABCC4 PTPN4 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.