ACTN4 FISH Probe
The ACTN4 FISH probe is designed to hybridize to the ACTN4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACTN4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| ACTN4-20-RE | 20 (40 μL) | 200 μL |  |
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| ACTN4-20-GO | 20 (40 μL) | 200 μL |  |
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| ACTN4-20-GR | 20 (40 μL) | 200 μL |  |
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| ACTN4-20-AQ | 20 (40 μL) | 200 μL |  |
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| ACTN4-20-DIG | 20 (40 μL) | 200 μL |  |
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| ACTN4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: ACTN4
Gene Name: Actinin Alpha 4
Chromosome: CHR19: 39138266-39221171
Locus: 19q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: ACTN4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ACTN4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping