APP FISH Probe
The APP FISH probe is designed to hybridize to the APP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APP-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| APP-20-RE | 20 (40 μL) | 200 μL |  |
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| APP-20-GO | 20 (40 μL) | 200 μL |  |
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| APP-20-GR | 20 (40 μL) | 200 μL |  |
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| APP-20-AQ | 20 (40 μL) | 200 μL |  |
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| APP-20-DIG | 20 (40 μL) | 200 μL |  |
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| APP-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Gene Details
Gene Symbol: APP
Gene Name: Amyloid Beta Precursor Protein
Chromosome: CHR21: 27252860-27543446
Locus: 21q21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: APP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: APP-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping