C4A FISH Probe
The C4A FISH probe is designed to hybridize to the C4A gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| C4A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| C4A-20-RE | 20 (40 μL) | 200 μL |  |
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| C4A-20-GO | 20 (40 μL) | 200 μL |  |
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| C4A-20-GR | 20 (40 μL) | 200 μL |  |
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| C4A-20-AQ | 20 (40 μL) | 200 μL |  |
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| C4A-20-DIG | 20 (40 μL) | 200 μL |  |
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| C4A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Gene Details
Gene Symbol: C4A
Gene Name: Complement C4A (Rodgers Blood Group)
Chromosome: CHR6_qbl_hap6: 3243623-3264248
Locus: 6p21.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: C4A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: C4A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping