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CCND2 Break Apart FISH Probe

Empire Genomics’ CCND2 Break Apart FISH Probe is designed to flank the CCND2 gene and is typically used for detecting CCND2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CCND2BA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CCND2BA-20-AQOR 20 (40 μL) 200 μL
CCND2BA-20-GOGR 20 (40 μL) 200 μL
CCND2BA-20-GORE 20 (40 μL) 200 μL
CCND2BA-20-GRGO 20 (40 μL) 200 μL
CCND2BA-20-GROR 20 (40 μL) 200 μL
CCND2BA-20-GRRE 20 (40 μL) 200 μL
CCND2BA-20-REGO 20 (40 μL) 200 μL
CCND2BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]

Gene Details

Gene Symbol: CCND2

Gene Name: Cyclin D2

Chromosome: CHR12: 4382901-4414522

Locus: 12p13.32

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

A patient with a diagnosis of nodal marginal zone B-cell lymphoma and a t(2;14)(p24;q32) involving MYCN and IGH

The MYCN-IGH fusion has been described in blastic mantle cell lymphoma and follicular lymphoma, but, at the time of this study, still hadn’t been identified in marginal zone B-cell lymphoma (MZL). This study presented the first documented case of MYCN-IGH fusion in a MZL patient. Cytogenetic testing, including FISH, was performed to analyze the patient’s genome. Our CCND2 break apart probe and RP11-542H15 BAC FISH probe were used to detect CCND2 and MYCN rearrangements.

Product Details

Product: CCND2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: CCND2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping