CEP57 FISH Probe
The CEP57 FISH probe is designed to hybridize to the CEP57 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CEP57-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CEP57-20-RE | 20 (40 μL) | 200 μL |  |
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| CEP57-20-GO | 20 (40 μL) | 200 μL |  |
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| CEP57-20-GR | 20 (40 μL) | 200 μL |  |
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| CEP57-20-AQ | 20 (40 μL) | 200 μL |  |
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| CEP57-20-DIG | 20 (40 μL) | 200 μL |  |
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| CEP57-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Details
Gene Symbol: CEP57
Gene Name: Centrosomal Protein 57
Chromosome: CHR11: 95523624-95565857
Locus: 11q21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CEP57 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CEP57-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping