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CIC Break Apart FISH Probe

Empire Genomics’ CIC Break Apart FISH Probe is designed to flank the CIC gene and is typically used for detecting CIC rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
CICBA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CICBA-20-AQOR 20 (40 μL) 200 μL
CICBA-20-GOGR 20 (40 μL) 200 μL
CICBA-20-GORE 20 (40 μL) 200 μL
CICBA-20-GRGO 20 (40 μL) 200 μL
CICBA-20-GROR 20 (40 μL) 200 μL
CICBA-20-GRRE 20 (40 μL) 200 μL
CICBA-20-REGO 20 (40 μL) 200 μL
CICBA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

Gene Details

Gene Symbol: CIC

Gene Name: Capicua Transcriptional Repressor

Chromosome: CHR19: 42788816-42799949

Locus: 19q13.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Clinicopathologic Features of CIC-NUTM1 Sarcomas, a New Molecular Variant of the Family of CIC-Fused Sarcomas

CIC-fused sarcomas are round cell sarcomas first identified in 2006, characterized by recurrent CIC fusions with a variety of genes, including DUX4 and FOXO4. Recent studies have implicated NUTM1 as a potential new CIC fusion partner in these tumors. This team sought to determine the frequency of NUTM1 translocations in 6 cases of CIC-rearranged sarcoma. Empire Genomics’ CIC break apart probe was used to verify the presence of CIC translocations in the samples. All cases tested positive for NUTM1 rearrangement, suggesting CIC-NUTM1 fused cases represent a new subset of CIC-fused sarcomas.
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Product Details

Product: CIC FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: CIC-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping