COX10 FISH Probe
The COX10 FISH probe is designed to hybridize to the COX10 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| COX10-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| COX10-20-RE | 20 (40 μL) | 200 μL |  |
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| COX10-20-GO | 20 (40 μL) | 200 μL |  |
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| COX10-20-GR | 20 (40 μL) | 200 μL |  |
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| COX10-20-AQ | 20 (40 μL) | 200 μL |  |
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| COX10-20-DIG | 20 (40 μL) | 200 μL |  |
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| COX10-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: COX10
Gene Name: COX10, Heme A:farnesyltransferase Cytochrome C Oxidase Assembly Factor
Chromosome: CHR17: 13972718-14111996
Locus: 17p12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: COX10 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: COX10-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping