CRYAB FISH Probe
The CRYAB FISH probe is designed to hybridize to the CRYAB gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CRYAB-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CRYAB-20-RE | 20 (40 μL) | 200 μL |  |
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| CRYAB-20-GO | 20 (40 μL) | 200 μL |  |
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| CRYAB-20-GR | 20 (40 μL) | 200 μL |  |
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| CRYAB-20-AQ | 20 (40 μL) | 200 μL |  |
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| CRYAB-20-DIG | 20 (40 μL) | 200 μL |  |
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| CRYAB-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Details
Gene Symbol: CRYAB
Gene Name: Crystallin Alpha B
Chromosome: CHR11: 111779349-111782473
Locus: 11q23.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CRYAB FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CRYAB-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping