DDB1 FISH Probe
The DDB1 FISH probe is designed to hybridize to the DDB1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DDB1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DDB1-20-RE | 20 (40 μL) | 200 μL |  |
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| DDB1-20-GO | 20 (40 μL) | 200 μL |  |
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| DDB1-20-GR | 20 (40 μL) | 200 μL |  |
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| DDB1-20-AQ | 20 (40 μL) | 200 μL |  |
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| DDB1-20-DIG | 20 (40 μL) | 200 μL |  |
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| DDB1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]
Gene Details
Gene Symbol: DDB1
Gene Name: Damage Specific DNA Binding Protein 1
Chromosome: CHR11: 61066918-61100666
Locus: 11q12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DDB1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DDB1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping