DMPK FISH Probe
The DMPK FISH probe is designed to hybridize to the DMPK gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DMPK-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DMPK-20-RE | 20 (40 μL) | 200 μL |  |
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| DMPK-20-GO | 20 (40 μL) | 200 μL |  |
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| DMPK-20-GR | 20 (40 μL) | 200 μL |  |
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| DMPK-20-AQ | 20 (40 μL) | 200 μL |  |
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| DMPK-20-DIG | 20 (40 μL) | 200 μL |  |
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| DMPK-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]
Gene Details
Gene Symbol: DMPK
Gene Name: DM1 Protein Kinase
Chromosome: CHR19: 46272975-46285815
Locus: 19q13.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DMPK FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DMPK-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping