ESPL1 FISH Probe
The ESPL1 FISH probe is designed to hybridize to the ESPL1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ESPL1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| ESPL1-20-RE | 20 (40 μL) | 200 μL |  |
|
| ESPL1-20-GO | 20 (40 μL) | 200 μL |  |
|
| ESPL1-20-GR | 20 (40 μL) | 200 μL |  |
|
| ESPL1-20-AQ | 20 (40 μL) | 200 μL |  |
|
| ESPL1-20-DIG | 20 (40 μL) | 200 μL |  |
|
| ESPL1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]
Gene Details
Gene Symbol: ESPL1
Gene Name: Extra Spindle Pole Bodies Like 1, Separase
Chromosome: CHR12: 53662082-53687427
Locus: 12q13.13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: ESPL1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ESPL1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping