FEN1 FISH Probe
The FEN1 FISH probe is designed to hybridize to the FEN1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FEN1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FEN1-20-RE | 20 (40 μL) | 200 μL |  |
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| FEN1-20-GO | 20 (40 μL) | 200 μL |  |
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| FEN1-20-GR | 20 (40 μL) | 200 μL |  |
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| FEN1-20-AQ | 20 (40 μL) | 200 μL |  |
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| FEN1-20-DIG | 20 (40 μL) | 200 μL |  |
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| FEN1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: FEN1
Gene Name: Flap Structure-specific Endonuclease 1
Chromosome: CHR11: 61560108-61564714
Locus: 11q12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: FEN1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FEN1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping