GALE FISH Probe
The GALE FISH probe is designed to hybridize to the GALE gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GALE-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| GALE-20-RE | 20 (40 μL) | 200 μL |  |
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| GALE-20-GO | 20 (40 μL) | 200 μL |  |
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| GALE-20-GR | 20 (40 μL) | 200 μL |  |
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| GALE-20-AQ | 20 (40 μL) | 200 μL |  |
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| GALE-20-DIG | 20 (40 μL) | 200 μL |  |
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| GALE-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and cognitive disability, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: GALE
Gene Name: UDP-galactose-4-epimerase
Chromosome: CHR1: 24122088-24127294
Locus: 1p36.11
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: GALE FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GALE-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping