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GCH1 FISH Probe

The GCH1 FISH probe is designed to hybridize to the GCH1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

SKU Test Kits Buffer Dye Color Order Now
GCH1-20-OR  (Standard Design) 20 (40 μL) 200 μL
GCH1-20-RE 20 (40 μL) 200 μL
GCH1-20-GO 20 (40 μL) 200 μL
GCH1-20-GR 20 (40 μL) 200 μL
GCH1-20-AQ 20 (40 μL) 200 μL
GCH1-20-DIG 20 (40 μL) 200 μL
GCH1-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: GCH1

Gene Name: GTP Cyclohydrolase 1

Chromosome: CHR14: 55308723-55369542

Locus: 14q22.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: GCH1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: GCH1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping