IL12B FISH Probe
The IL12B FISH probe is designed to hybridize to the IL12B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IL12B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| IL12B-20-RE | 20 (40 μL) | 200 μL |  |
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| IL12B-20-GO | 20 (40 μL) | 200 μL |  |
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| IL12B-20-GR | 20 (40 μL) | 200 μL |  |
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| IL12B-20-AQ | 20 (40 μL) | 200 μL |  |
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| IL12B-20-DIG | 20 (40 μL) | 200 μL |  |
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| IL12B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: IL12B
Gene Name: Interleukin 12B
Chromosome: CHR5: 158741790-158757481
Locus: 5q33.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IL12B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IL12B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping