KPNA2 FISH Probe
The KPNA2 FISH probe is designed to hybridize to the KPNA2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KPNA2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| KPNA2-20-RE | 20 (40 μL) | 200 μL |  |
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| KPNA2-20-GO | 20 (40 μL) | 200 μL |  |
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| KPNA2-20-GR | 20 (40 μL) | 200 μL |  |
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| KPNA2-20-AQ | 20 (40 μL) | 200 μL |  |
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| KPNA2-20-DIG | 20 (40 μL) | 200 μL |  |
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| KPNA2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Details
Gene Symbol: KPNA2
Gene Name: Karyopherin Subunit Alpha 2
Chromosome: CHR17: 66031847-66042970
Locus: 17q24.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: KPNA2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KPNA2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping