LDLR FISH Probe
The LDLR FISH probe is designed to hybridize to the LDLR gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LDLR-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| LDLR-20-RE | 20 (40 μL) | 200 μL |  |
|
| LDLR-20-GO | 20 (40 μL) | 200 μL |  |
|
| LDLR-20-GR | 20 (40 μL) | 200 μL |  |
|
| LDLR-20-AQ | 20 (40 μL) | 200 μL |  |
|
| LDLR-20-DIG | 20 (40 μL) | 200 μL |  |
|
| LDLR-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Gene Details
Gene Symbol: LDLR
Gene Name: Low Density Lipoprotein Receptor
Chromosome: CHR19: 11200037-11244505
Locus: 19p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: LDLR FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: LDLR-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping