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LRTOMT FISH Probe

The LRTOMT FISH probe is designed to hybridize to the LRTOMT gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
LRTOMT-20-OR  (Standard Design) 20 (40 μL) 200 μL
LRTOMT-20-RE 20 (40 μL) 200 μL
LRTOMT-20-GO 20 (40 μL) 200 μL
LRTOMT-20-GR 20 (40 μL) 200 μL
LRTOMT-20-AQ 20 (40 μL) 200 μL
LRTOMT-20-DIG 20 (40 μL) 200 μL
LRTOMT-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene has evolved in primates as a fusion of two ancestral neighboring genes, Lrrc51 and Tomt, which exist as two independent genes in rodents. The fusion gene contains some shared exons, but encodes structurally unrelated proteins, LRTOMT1 and LRTOMT2. Those variants that utilize the more centromere-proximal 3' terminal exon (short transcript form) encode LRTOMT1, while those variants that use a more centromere-distal 3' terminal exon (long transcript form) encode the LRTOMT2 protein. There is a small region within one of the exons of this gene that contains overlapping alternate reading frames for both LRTOMT1 and LRTOMT2. LRTOMT1 shares similarity with the protein encoded by mouse Lrrc51, while LRTOMT2 shares similarity with the protein encoded by mouse Tomt. Alternative splicing results in multiple transcript variants, encoding different isoforms of both LRTOMT1 and LRTOMT2. The LRTOMT1 protein is a leucine-rich repeat-containing protein, while the LRTOMT2 protein is a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. [provided by RefSeq, Nov 2017]

Gene Details

Gene Symbol: LRTOMT

Gene Name: Leucine Rich Transmembrane And O-methyltransferase Domain Containing

Chromosome: CHR11: 71791376-71821828

Locus: 11q13.4

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: LRTOMT FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: LRTOMT-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping