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MAML2 FISH Probe

The MAML2 FISH probe is designed to hybridize to the MAML2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

SKU Test Kits Buffer Dye Color Order Now
MAML2-20-OR  (Standard Design) 20 (40 μL) 200 μL
MAML2-20-RE 20 (40 μL) 200 μL
MAML2-20-GO 20 (40 μL) 200 μL
MAML2-20-GR 20 (40 μL) 200 μL
MAML2-20-AQ 20 (40 μL) 200 μL
MAML2-20-DIG 20 (40 μL) 200 μL
MAML2-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]

Gene Details

Gene Symbol: MAML2

Gene Name: Mastermind Like Transcriptional Coactivator 2

Chromosome: CHR11: 95711439-96076344

Locus: 11q21

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: MAML2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: MAML2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping