NARF FISH Probe
The NARF FISH probe is designed to hybridize to the NARF gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NARF-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NARF-20-RE | 20 (40 μL) | 200 μL |  |
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| NARF-20-GO | 20 (40 μL) | 200 μL |  |
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| NARF-20-GR | 20 (40 μL) | 200 μL |  |
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| NARF-20-AQ | 20 (40 μL) | 200 μL |  |
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| NARF-20-DIG | 20 (40 μL) | 200 μL |  |
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| NARF-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: NARF
Gene Name: Nuclear Prelamin A Recognition Factor
Chromosome: CHR17: 80416059-80446143
Locus: 17q25.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NARF FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NARF-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping