NR1I3 FISH Probe
The NR1I3 FISH probe is designed to hybridize to the NR1I3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NR1I3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NR1I3-20-RE | 20 (40 μL) | 200 μL |  |
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| NR1I3-20-GO | 20 (40 μL) | 200 μL |  |
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| NR1I3-20-GR | 20 (40 μL) | 200 μL |  |
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| NR1I3-20-AQ | 20 (40 μL) | 200 μL |  |
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| NR1I3-20-DIG | 20 (40 μL) | 200 μL |  |
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| NR1I3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: NR1I3
Gene Name: Nuclear Receptor Subfamily 1 Group I Member 3
Chromosome: CHR1: 161199455-161208000
Locus: 1q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NR1I3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NR1I3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping