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PFKFB4 FISH Probe

The PFKFB4 FISH probe is designed to hybridize to the PFKFB4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PFKFB4-20-OR  (Standard Design) 20 (40 μL) 200 μL
PFKFB4-20-RE 20 (40 μL) 200 μL
PFKFB4-20-GO 20 (40 μL) 200 μL
PFKFB4-20-GR 20 (40 μL) 200 μL
PFKFB4-20-AQ 20 (40 μL) 200 μL
PFKFB4-20-DIG 20 (40 μL) 200 μL
PFKFB4-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Gene Details

Gene Symbol: PFKFB4

Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

Chromosome: CHR3: 48555116-48594227

Locus: 3p21.31

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: PFKFB4 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PFKFB4-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping