POLH FISH Probe
The POLH FISH probe is designed to hybridize to the POLH gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| POLH-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| POLH-20-RE | 20 (40 μL) | 200 μL |  |
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| POLH-20-GO | 20 (40 μL) | 200 μL |  |
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| POLH-20-GR | 20 (40 μL) | 200 μL |  |
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| POLH-20-AQ | 20 (40 μL) | 200 μL |  |
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| POLH-20-DIG | 20 (40 μL) | 200 μL |  |
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| POLH-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Details
Gene Symbol: POLH
Gene Name: DNA Polymerase Eta
Chromosome: CHR6: 43543877-43588260
Locus: 6p21.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: POLH FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: POLH-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping