PPM1A FISH Probe
The PPM1A FISH probe is designed to hybridize to the PPM1A gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PPM1A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PPM1A-20-RE | 20 (40 μL) | 200 μL |  |
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| PPM1A-20-GO | 20 (40 μL) | 200 μL |  |
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| PPM1A-20-GR | 20 (40 μL) | 200 μL |  |
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| PPM1A-20-AQ | 20 (40 μL) | 200 μL |  |
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| PPM1A-20-DIG | 20 (40 μL) | 200 μL |  |
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| PPM1A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PPM1A
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1A
Chromosome: CHR14: 60712469-60765805
Locus: 14q23.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PPM1A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PPM1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping