RNF43 FISH Probe
The RNF43 FISH probe is designed to hybridize to the RNF43 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF43-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RNF43-20-RE | 20 (40 μL) | 200 μL |  |
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| RNF43-20-GO | 20 (40 μL) | 200 μL |  |
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| RNF43-20-GR | 20 (40 μL) | 200 μL |  |
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| RNF43-20-AQ | 20 (40 μL) | 200 μL |  |
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| RNF43-20-DIG | 20 (40 μL) | 200 μL |  |
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| RNF43-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Gene Details
Gene Symbol: RNF43
Gene Name: Ring Finger Protein 43
Chromosome: CHR17: 56431037-56494931
Locus: 17q22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: RNF43 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RNF43-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping