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RPE65 FISH Probe

The RPE65 FISH probe is designed to hybridize to the RPE65 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

SKU Test Kits Buffer Dye Color Order Now
RPE65-20-OR  (Standard Design) 20 (40 μL) 200 μL
RPE65-20-RE 20 (40 μL) 200 μL
RPE65-20-GO 20 (40 μL) 200 μL
RPE65-20-GR 20 (40 μL) 200 μL
RPE65-20-AQ 20 (40 μL) 200 μL
RPE65-20-DIG 20 (40 μL) 200 μL
RPE65-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017]

Gene Details

Gene Symbol: RPE65

Gene Name: RPE65, Retinoid Isomerohydrolase

Chromosome: CHR1: 68894506-68915642

Locus: 1p31.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: RPE65 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: RPE65-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping