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STIL Break Apart FISH Probe

Empire Genomics’ STIL Break Apart FISH Probe is designed to flank the STIL gene and is typically used for detecting STIL rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
STILBA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
STILBA-20-AQOR 20 (40 μL) 200 μL
STILBA-20-GOGR 20 (40 μL) 200 μL
STILBA-20-GORE 20 (40 μL) 200 μL
STILBA-20-GRGO 20 (40 μL) 200 μL
STILBA-20-GRRE 20 (40 μL) 200 μL
STILBA-20-ORGR 20 (40 μL) 200 μL
STILBA-20-REGO 20 (40 μL) 200 μL
STILBA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: STIL

Gene Name: STIL, Centriolar Assembly Protein

Chromosome: CHR1: 47715810-47779819

Locus: 1p33

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Chromosomal instability associated with adverse outcome: a case report of patient with Nijmegen breakage syndrome and rapidly developed T-NHL with complex karyotype

Nijmegen breakage syndrome (NBS) is a rare genetic disorder associated with an increased risk of developing lymphoproliferative malignancy. The lack of data around NBS genetics has led to limited biomarker validation and underdeveloped diagnostic protocols. This team followed a 4 year-old NBS patient, from initial diagnosis to eventual development to non-Hodgkin lymphoma, and tracked the genetic progression of his disease throughout. Our STIL break apart probe detected STIL duplication in the patient, one of the many lesions contributing to his complex karyotype.
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Product Details

Product: STIL FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: STIL-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping