TCL1A FISH Probe
The TCL1A FISH probe is designed to hybridize to the TCL1A gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TCL1A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TCL1A-20-RE | 20 (40 μL) | 200 μL |  |
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| TCL1A-20-GO | 20 (40 μL) | 200 μL |  |
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| TCL1A-20-GR | 20 (40 μL) | 200 μL |  |
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| TCL1A-20-AQ | 20 (40 μL) | 200 μL |  |
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| TCL1A-20-DIG | 20 (40 μL) | 200 μL |  |
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| TCL1A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Gene Details
Gene Symbol: TCL1A
Gene Name: T-cell Leukemia/lymphoma 1A
Chromosome: CHR14: 96176303-96180533
Locus: 14q32.13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TCL1A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TCL1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping