TFE3 Break Apart FISH Probe

Empire Genomics’ TFE3 Break Apart FISH Probe is designed to flank the TFE3 gene and is typically used for detecting TFE3 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days Shipping Time: 1-2 Day Expedited Shipping

Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU	Test Kits	Buffer
TFE3BA-20-GROR (Standard Design)	20 (40 μL)	200 μL
TFE3BA-20-AQOR	20 (40 μL)	200 μL
TFE3BA-20-GOGR	20 (40 μL)	200 μL
TFE3BA-20-GORE	20 (40 μL)	200 μL
TFE3BA-20-GRGO	20 (40 μL)	200 μL
TFE3BA-20-GRRE	20 (40 μL)	200 μL
TFE3BA-20-ORGR	20 (40 μL)	200 μL
TFE3BA-20-REGO	20 (40 μL)	200 μL
TFE3BA-20-REGR	20 (40 μL)	200 μL

Gene Summary

This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Details

Gene Symbol: TFE3

Gene Name: Transcription Factor Binding To IGHM Enhancer 3

Chromosome: CHRX: 48886241-48900990

Locus: Xp11.23

FISH Probe Protocols

Protocol, Procedure, or Form Name	Last Modified	Download

Detection of 6 TFEB-amplified renal cell carcinomas and 25 renal cell carcinomas with MITF translocations: systematic morphologic analysis of 85 cases evaluated by clinical TFE3 and TFEB FISH assays

Renal cell carcinomas with MITF family abnormalities display diverse morphologies. In order to better understand the association between MITF alterations and clinicopathologic characteristics, this team performed FISH analysis on 85 renal tumors using our TFE3 and TFEB break apart probes.

Alveolar soft-part sarcoma of the prostate: a case report and review of the literature

Alveolar soft-part sarcoma (ASPS) is a rare malignant soft tissue tumor. The subject of this study was a 21 year old man who presented with ASPS of the prostate. Our ASPL and TFE3 break apart probes were used to confirm fusion of the two genes in the patient’s tumor, helping to elucidate the underlying genetic drivers of this extremely rare, aggressive neoplasm.

Gastric Perivascular Epithelioid Cell Tumor (PEComa): A Morphologic, Immunohistochemical, and Molecular Study Cell Tumor (PEComa)

Gastric Perivascular epithelioid cell tumor (PEComa) is an extremely rare tumor type - at the time of the study, only 7 cases had been reported so far. In this study, 2 new cases of PEComa were histologically and cytogenetically analyzed. In light of a recent study on a case of PEComa that harbored TFE3 fusion (and also exhibited unique features not typical of conventional PEComa), the tumors were screened for TFE3 rearrangements using Empire Genomics' TFE3 break-apart probe. Neither of the tumors were found to display TFE3 translocations.

Clinicopathological Characterization of Renal Cell Carcinoma in Young Adults: a contemporary update and review of literature

Compared to adult renal cell carcinoma (RCC), pediatric and young adult RCC is fairly rare and poorly characterized. This team wanted to explore the genetic, molecular, and clinical spectrum of childhood and young adult RCC. They analyzed 68 RCC patients, all age 30 years or younger, using IHC and FISH. Our TFE3 and TFEB break apart FISH probes were used to detect rearrangements of the genes in cases that were morphologically suspicious for TFE3/TFEB translocations.

Product Details

Product: TFE3 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: TFE3-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping

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