TOP2B FISH Probe
The TOP2B FISH probe is designed to hybridize to the TOP2B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TOP2B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TOP2B-20-RE | 20 (40 μL) | 200 μL |  |
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| TOP2B-20-GO | 20 (40 μL) | 200 μL |  |
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| TOP2B-20-GR | 20 (40 μL) | 200 μL |  |
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| TOP2B-20-AQ | 20 (40 μL) | 200 μL |  |
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| TOP2B-20-DIG | 20 (40 μL) | 200 μL |  |
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| TOP2B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Details
Gene Symbol: TOP2B
Gene Name: DNA Topoisomerase II Beta
Chromosome: CHR3: 25639474-25705788
Locus: 3p24.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TOP2B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TOP2B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping