ERBB2 (HER2) FISH Probe
Our ERBB2 probe is designed to detect ERBB2 amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs.
Gene Background: ERBB2 is a member of the receptor tyrosine kinase family, a subset of receptor proteins that bind epidermal growth factor (EGF).1 ERBB2 doesn’t have a binding domain itself, but stabilizes the configurations of other receptor proteins, making it easier for EGF to latch on.1 ERBB2 is involved in a lengthy list of important signaling cascades, as EGF is a ubiquitous mitogenic factor that stimulates cell growth in many tissue types.2 ERBB2’s oncogenic effects first came to light in 1987, when it was found to play a major role in breast cancer metastasis.3 The gene remains primarily associated with breast cancer (20-30% of breast cancer patients have amplified ERBB2) but it’s now also considered an important oncogene in uterine, gastric, pancreatic, colorectal and endometrial cancer, among others.4,5
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
|SKU||Test Kits||Buffer||Dye Color||Order Now|
|ERBB2-20-OR (Standard Design)||20 (40 μL)||200 μL|
|ERBB2-20-GO||20 (40 μL)||200 μL|
|ERBB2-20-GR||20 (40 μL)||200 μL|
|ERBB2-20-AQ||20 (40 μL)||200 μL|
|ERBB2-20-RE||20 (40 μL)||200 μL|
FISH Probe Protocols
|Protocol, Procedure, or Form Name||Last Modified||Download|