NTRK1 Break Apart FISH Probe
Our NTRK1 Break Apart probe is designed to detect NTRK1 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: NTRK1, which belongs to the same neurotrophin receptor family that includes NTRK2 and NTRK3, encodes a tyrosine kinase that binds nerve growth factor (NGF). The gene is critical to central and peripheral nervous system development, helping to regulate proliferation, differentiation, and apoptosis in neural cells. NTRK1 rearrangements, which generally result in fusions with partner genes that constitutively activate NTRK1’s kinase domain, have been identified in a number of human cancers. These include colon carcinoma, papillary thyroid carcinoma, lung cancer, glioblastoma, and melanoma.
Source: Amatu A, et al. (2016) ESMO open 1.2: e000023.
Available as CE marked product in certain countries
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NTRK1BA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NTRK1BA-20-GOGR | 20 (40 μL) | 200 μL |
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| NTRK1BA-20-GRRE | 20 (40 μL) | 200 μL |
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| NTRK1BA-20-REGR | 20 (40 μL) | 200 μL |
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| NTRK1BA-20-REGO | 20 (40 μL) | 200 μL |
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| NTRK1BA-20-GROR | 20 (40 μL) | 200 μL |
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| NTRK1BA-20-GRGO | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: NTRK1
Gene Name: Neurotrophic Receptor Tyrosine Kinase 1
Chromosome: CHR1: 156785541-156851642
Locus: 1q23.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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