MULTICOLOR PROBE KIT
NTRK1, NTRK2, and NTRK3 code for the receptors TRKA, TRKB, and TRKC respectively. Each of the TRK receptors is activated by a different binding factor, which triggers phosphorylation of the proteins’ intracellular kinase domain, setting off various signaling pathways that ultimately lead to central and peripheral nervous system development1.
NTRK genes almost always become oncogenic through the same mechanism: the gene’s 3’ region fuses with the 5’ sequence of a partner gene, creating a chimeric fusion protein with a constitutively activated NTRK kinase domain. This leads to deregulated neural development – neuron growth, differentiation, proliferation, and apoptosis all fall into disarray, and important synaptic pathways are compromised1.
So far, NTRK fusions have been found to occur with around 90% frequency in a collection of relatively rare cancers (secretory breast carcinoma, mammary analogue secretory carcinoma, cellular or mixed congenital mesoblastic nephroma and infantile fibrosarcoma), and lower frequency in a variety of other malignancies (non-small cell lung cancer, colorectal carcinoma, and acute myeloid leukemia, to name a few). NTRK aberrations have also been implicated in certain neuronal disorders, including anhidrosis, epilepsy and depression1.
TRK proteins are receptor tyrosine kinases, like the clinically significant ALK gene, which allow them to be targeted by the same medications that are used in patients with ALK aberrations2. In 2017, the tyrosine kinase inhibitors entrectinib and larotrectinib were granted FDA breakthrough designation for the treatment of NTRK fusion-positive solid tumors3.
- Amatu, Alessio, Andrea Sartore-Bianchi, and Salvatore Siena. "NTRK gene fusions as novel targets of cancer therapy across multiple tumour types." ESMO open 1.2 (2016): e000023.
- Raez, Luis E., and Christian Rolfo. "Neurotrophic tyrosine kinase gene fusions: another opportunity for targeting in lung cancer." (2016): 1-4.
- Cocco, E., Scaltriti, M., & Drilon, A. (2018). NTRK fusion-positive cancers and TRK inhibitor therapy. Nature Reviews Clinical Oncology, 1.
|PROBE NAME||REGION||TESTS||DYE COLOR||SKU||ACTIONS|
|NTRK1 Break Apart FISH Probe||
|NTRK2 Break Apart FISH Probe||
|NTRK3 Break Apart FISH Probe||
Request More Information & Your Free Sample
Are you interested in our multicolor kit but still have questions? Send us a message with the specific probes you're interested in and we'll send you a free sample to try out.