TMPRSS2 FISH Probe
This gene was shown to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The TMPRSS2-ERG fusion is specific for prostate cancer and occurs in approximately 50% of prostate tumors. Empire Genomics has developed a TMPRSS2 FISH Probe which can be used to detect TMPRSS2 gene rearrangements. The probe comes labeled in aqua, and you may also choose to customize the probe to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| TMPRSS2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |
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| TMPRSS2-20-AQ | 20 (40 μL) | 200 μL |
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| TMPRSS2-20-GR | 20 (40 μL) | 200 μL |
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| TMPRSS2-20-GO | 20 (40 μL) | 200 μL |
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| TMPRSS2-20-RE | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Details
Gene Symbol: TMPRSS2
Gene Name: Transmembrane Protease, Serine 2
Chromosome: CHR21: 42836477-42880085
Locus: 21q22.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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