PAX5 FISH Probe
Our PAX5 FISH probe is designed to detect PAX5 amplifications and deletions. The probe comes orange, but can be customized to meet your needs.
Gene Background: PAX5 regulates differentiation of B-cells, monitoring their development from pro-B to mature B cell stage until terminal differentiation into plasma cells.1 PAX5 translocations result in fusion genes encoding chimeric proteins with altered PAX5 function, and occur in 2–3% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients.1 The gene is a promiscuous fusion partner, with over 16 partner genes now identified in leukemia-associated fusions.2
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAX5-20-OR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAX5-20-RE | 20 (40 μL) | 200 μL |
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| PAX5-20-AQ | 20 (40 μL) | 200 μL |
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| PAX5-20-GR | 20 (40 μL) | 200 μL |
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| PAX5-20-GO | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Details
Gene Symbol: PAX5
Gene Name: Paired Box 5
Chromosome: CHR9: 36838530-37034476
Locus: 9p13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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