NTRK1 Break Apart FISH Probe

Empire Genomics' NTRK1 Break Apart FISH probe is designed to detect rearrangements of the NTRK1 gene at chromosomal region 1q23.1. The probe comes labeled in orange and green, but can be customized to meet your needs. A normal signal pattern will show two sets of overlapping orange and green signals. An abnormal pattern will show at least one set of split orange and green signals, indicating NTRK1 translocation.

Gene Background: NTRK1, which belongs to the same neurotrophin receptor family that includes NTRK2 and NTRK3, encodes a tyrosine kinase that binds nerve growth factor (NGF). The gene is critical to central and peripheral nervous system development, helping to regulate proliferation, differentiation, and apoptosis in neural cells. NTRK1 rearrangements, which generally result in fusions with partner genes that constitutively activate NTRK1’s kinase domain, have been identified in a number of human cancers. These include colon carcinoma, papillary thyroid carcinoma, lung cancer, glioblastoma, and melanoma.

Source: Amatu A, et al. (2016) ESMO open 1.2: e000023.

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SKU Test Kits Buffer Dye Color Order Now
NTRK1BA-20-ORGR  (Standard Design) 20 (40μL) 200 μL
NTRK1BA-20-GOGR 20 (40μL) 200 μL
NTRK1BA-20-GRRE 20 (40μL) 200 μL
NTRK1BA-20-REGR 20 (40μL) 200 μL
NTRK1BA-20-REGO 20 (40μL) 200 μL
NTRK1BA-20-GROR 20 (40μL) 200 μL
NTRK1BA-20-GRGO 20 (40μL) 200 μL