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NTRK1 Break Apart FISH Probe

Our NTRK1 Break Apart probe is designed to detect NTRK1 translocations. The probe comes labeled in orange and green, but can be customized to meet your needs. 

Gene Background: NTRK1, which belongs to the same neurotrophin receptor family that includes NTRK2 and NTRK3, encodes a tyrosine kinase that binds nerve growth factor (NGF). The gene is critical to central and peripheral nervous system development, helping to regulate proliferation, differentiation, and apoptosis in neural cells. NTRK1 rearrangements, which generally result in fusions with partner genes that constitutively activate NTRK1’s kinase domain, have been identified in a number of human cancers. These include colon carcinoma, papillary thyroid carcinoma, lung cancer, glioblastoma, and melanoma.

Source: Amatu A, et al. (2016) ESMO open 1.2: e000023.

Available as CE marked product in certain countries

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NTRK1BA-20-ORGR  (Standard Design) 20 (40μL) 200 μL
NTRK1BA-20-GOGR 20 (40μL) 200 μL
NTRK1BA-20-GRRE 20 (40μL) 200 μL
NTRK1BA-20-REGR 20 (40μL) 200 μL
NTRK1BA-20-REGO 20 (40μL) 200 μL
NTRK1BA-20-GROR 20 (40μL) 200 μL
NTRK1BA-20-GRGO 20 (40μL) 200 μL

Gene Summary

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: NTRK1

Gene Name: Neurotrophic Receptor Tyrosine Kinase 1

Chromosome: CHR1: 156785541-156851642

Locus: 1q23.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

TRKA expression and NTRK1 gene copy number across solid tumours

Our NTRK1 break apart probe was used to detect NTRK1 rearrangements in solid tumors from more than 1,000 patients. Over 14 different cancer types were analyzed, including lung, colorectal, and breast. NTRK1 translocations were identified in 5.9% of patients.

TRKA expression and NTRK1 gene copy number across solid tumours

Our NTRK1 break apart probe was used to detect NTRK1 rearrangements in solid tumors from more than 1,000 patients. Over 14 different cancer types were analyzed, including lung, colorectal, and breast. NTRK1 translocations were identified in 5.9% of patients.

Atypical Spitzoid Neoplasms in Childhood: A Molecular and Outcome Study

Atypical spitzoid neoplasms (APNs) are primarily pediatric lesions characterized by their intermediate features; clinically and histopathologically, they fall somewhere between benign spitz nevi and malignant melanoma. The genetics of these tumors are still poorly understood. In this study, 34 APNs were analyzed using FISH and IHC. Our ALK, BRAF, and NTRK1 break-apart FISH probes were used to detect rearrangements of the genes .

Identification and characterization of a novel SCYL3-NTRK1 rearrangement in a colorectal cancer patient

Our NTRK1 break apart probe helped to detect a new NTRK1 fusion in a 61 year old patient with adenocarcinoma of the right colon and pancreas. The team was able to verify that this novel fusion – SCYL3-NTRK1 – was in fact an oncogenic driver by transfecting cells with a SCYL3-NTRK1 cDNA construct, which lead to IL3-independent proliferation.