RPN1/MECOM Fusion FISH Probe
Our RPN1/MECOM fusion probe is designed to detect fusions between RPN1 and MECOM. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: MECOM codes for a transcriptional regulator that aids in cell proliferation, differentiation, and apoptosis, while RPN1 encodes a transmembrane glycoprotein found solely in the endoplasmic reticulum.1 Fusion of the genes, via inv(3)(q21q26), places RPN1’s promoter upstream of MECOM, resulting in MECOM overexpression.2 The fusion has been identified in de novo acute myeloid leukemia (AML), t-AML, sAML, myelodysplastic syndrome (MDS), chronic myelogenous leukemia (CML), and several other myeloproliferative disorders.1 It occurs in about 2-3% of adult AML, but is very rare in childhood cases.1
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPN1-MECOM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPN1-MECOM-20-GOGR | 20 (40 μL) | 200 μL |
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| RPN1-MECOM-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: RPN1
Gene Name: Ribophorin I
Chromosome: CHR3: 128338812-128369719
Locus: 3q21.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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