MECOM/RUNX1 FISH Probe
Our MECOM/RUNX1 fusion probe is designed to detect fusions between MECOM and RUNX1. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: RUNX1-MECOM fusions generate a hybrid transcript made up of the runt homology domain of RUNX1 and the two zinc-finger clusters of MECOM.1 The fusion contributes to oncogenesis via dominant negative regulation of RUNX1 in transcriptional activation, apoptotic resistance (from the first zinc-finger domain), and increased cellular proliferation (from the second zinc-finger domain).1 RUNX1-MECOM is a rare but recurrent finding in therapy-related myeloid neoplasms, CML with accelerated or blastic phase, and de novo AML.2
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MECOM-RUNX1-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| MECOM-RUNX1-20-GRRE | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Details
Gene Symbol: MECOM
Gene Name: MDS1 And EVI1 Complex Locus
Chromosome: CHR3: 168801286-169381563
Locus: 3q26.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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