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NTRK2 Break Apart FISH Probe

Our NTRK2 Break Apart Probe is designed to detect NTRK translocations. The probe comes labeled in orange and green but can be customized to meet your needs.

Gene Background: NTRK2 is a receptor tyrosine kinase that binds brain-derived growth factor (BDGF) and neurotrophin 4/5 (NT-4/5). The gene is essential to central and peripheral nervous system development and cell survival. NTRK2 rearrangements have been detected in many cancers, including glioblastoma, pilocytic astrocytoma, head and neck squamous cell carcinoma, and lung adenocarcinoma. These rearrangements generate fusion genes encoding hybrid proteins with ligand-independent TK activity, leading to unchecked cell proliferation and tumorigenesis.

Source: Amatu A, et al. (2016) ESMO open 1.2: e000023.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NTRK2BA-20-ORGR  (Standard Design) 20 (40μL) 200 μL
NTRK2BA-20-GOGR 20 (40μL) 200 μL
NTRK2BA-20-GRGO 20 (40μL) 200 μL
NTRK2BA-20-REGR 20 (40μL) 200 μL
NTRK2BA-20-REGO 20 (40μL) 200 μL

Gene Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Details

Gene Symbol: NTRK2

Gene Name: Neurotrophic Receptor Tyrosine Kinase 2

Chromosome: CHR9: 87283465-87638505

Locus: 9q21.33

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.