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FGFR2 FISH Probe

The FGFR2 FISH probe is designed to hybridize to the FGFR2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
FGFR2-20-OR  (Standard Design) 20 (40 μL) 200 μL
FGFR2-20-RE 20 (40 μL) 200 μL
FGFR2-20-GO 20 (40 μL) 200 μL
FGFR2-20-GR 20 (40 μL) 200 μL
FGFR2-20-AQ 20 (40 μL) 200 μL
FGFR2-20-DIG 20 (40 μL) 200 μL
FGFR2-20-BIO 20 (40 μL) 200 μL

Gene Summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Gene Details

Gene Symbol: FGFR2

Gene Name: Fibroblast Growth Factor Receptor 2

Chromosome: CHR10: 123237843-123357972

Locus: 10q26.13

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

FGFR2 amplification in colorectal adenocarcinoma

FGFR2 amplification occurs in about 5% of gastric cancers, but so far has only been reported in one colorectal cancer (CRC) cell line, where the cells were found to require FGFR2 amplification for survival. This was the first report of FGFR2 amplification in a CRC biopsy obtained directly from a patient’s primary tumor. Our FGFR2 FISH probe helped confirm FGFR2 amplification in the subject.

Product Details

Product: FGFR2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: FGFR2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping