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SEPT5 FISH Probe

The SEPT5 FISH probe is designed to hybridize to the SEPT5 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
SEPT5-20-OR  (Standard Design) 20 (40 μL) 200 μL
SEPT5-20-RE 20 (40 μL) 200 μL
SEPT5-20-GO 20 (40 μL) 200 μL
SEPT5-20-GR 20 (40 μL) 200 μL
SEPT5-20-AQ 20 (40 μL) 200 μL
SEPT5-20-DIG 20 (40 μL) 200 μL
SEPT5-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010]

Gene Details

Gene Symbol: SEPT5

Gene Name: Septin 5

Chromosome: CHR22: 19701986-19710845

Locus: 22q11.21

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Acute myeloid leukemia with KMT2A-SEPT5 translocation: A case report and review of the literature

Acute myeloid leukemia (AML) is commonly characterized by a chromosomal rearrangement of KMT2A. Up to 94 translocation partner genes have been identified thus far. This case study focuses on a rare gene translocation of KMT2A with SEPT5. FISH analysis was performed with two probes including our SEPT5 probe. FISH confirmed rearrangement of the KMT2A and SEPT5 genes. The study concluded that they had a new case of AML KMT2A-SEPT5 fusion, making it one of nine reported cases.
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Product Details

Product: SEPT5 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: SEPT5-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping