HPD-CYP2E1 Fusion FISH Probe
The HPD-CYP2E1 Fusion FISH Probe is used to confirm a fusion of the HPD and CYP2E1 genes. The fusion of the HPD and CYP2E1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| HPD-CYP2E1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-RERE | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-REOR | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-REGO | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-REGR | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-REAQ | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-ORRE | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-OROR | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-ORGO | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-ORAQ | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-GORE | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-GOOR | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-GOGO | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-GOGR | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-GOAQ | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-GRRE | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-GROR | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-GRGO | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-GRGR | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-GRAQ | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-AQRE | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-AQOR | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-AQGO | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-AQGR | 20 (40 μL) | 200 μL |
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| HPD-CYP2E1-20-AQAQ | 20 (40 μL) | 200 μL |
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CYP2E1 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome P450 Family 2 Subfamily E Member 1
Chromosome: CHR10: 135340866 -135352620
Locus: 10q26.3
HPD Gene Summary
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Name: 4-hydroxyphenylpyruvate Dioxygenase
Chromosome: CHR12: 122277432 -122326517
Locus: 12q24.31
Gene Diseases
The HPD CYP2E1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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