MAP3K12-GDF11 Fusion FISH Probe
The MAP3K12-GDF11 Fusion FISH Probe is used to confirm a fusion of the MAP3K12 and GDF11 genes. The fusion of the MAP3K12 and GDF11 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP3K12-GDF11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-RERE | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-REOR | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-REGO | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-REGR | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-OROR | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-GORE | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-GROR | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP3K12-GDF11-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP3K12 Gene Summary
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 12
Chromosome: CHR12: 53874275 -53893444
Locus: 12q13.13
GDF11 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]
Gene Name: Growth Differentiation Factor 11
Chromosome: CHR12: 56137063 -56146665
Locus: 12q13.2
Gene Diseases
The MAP3K12 GDF11 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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