NUP214-ABL1 Fusion FISH Probe
The NUP214-ABL1 Fusion FISH Probe is used to confirm a fusion of the NUP214 and ABL1 genes. The fusion of the NUP214 and ABL1 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUP214-ABL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-RERE | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-REOR | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-REGO | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-REGR | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-REAQ | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-ORRE | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-OROR | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-ORGO | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-GORE | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-GOOR | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-GOGO | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-GOGR | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-GRRE | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-GROR | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-GRGO | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-GRGR | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-AQRE | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-AQOR | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-AQGO | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-AQGR | 20 (40 μL) | 200 μL |
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| NUP214-ABL1-20-AQAQ | 20 (40 μL) | 200 μL |
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ABL1 Gene Summary
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Gene Name: ABL Proto-oncogene 1, Non-receptor Tyrosine Kinase
Chromosome: CHR9: 133589267 -133763062
Locus: 9q34.12
NUP214 Gene Summary
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: Nucleoporin 214
Chromosome: CHR9: 134000980 -134109091
Locus: 9q34.13
Gene Diseases
The NUP214 ABL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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