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NUP98-MLXIP Fusion FISH Probe

The NUP98-MLXIP Fusion FISH Probe is used to confirm a fusion of the NUP98 and MLXIP genes. The fusion of the NUP98 and MLXIP genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NUP98-MLXIP-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NUP98-MLXIP-20-RERE 20 (40 μL) 200 μL
NUP98-MLXIP-20-REOR 20 (40 μL) 200 μL
NUP98-MLXIP-20-REGO 20 (40 μL) 200 μL
NUP98-MLXIP-20-REGR 20 (40 μL) 200 μL
NUP98-MLXIP-20-REAQ 20 (40 μL) 200 μL
NUP98-MLXIP-20-ORRE 20 (40 μL) 200 μL
NUP98-MLXIP-20-OROR 20 (40 μL) 200 μL
NUP98-MLXIP-20-ORGO 20 (40 μL) 200 μL
NUP98-MLXIP-20-ORAQ 20 (40 μL) 200 μL
NUP98-MLXIP-20-GORE 20 (40 μL) 200 μL
NUP98-MLXIP-20-GOOR 20 (40 μL) 200 μL
NUP98-MLXIP-20-GOGO 20 (40 μL) 200 μL
NUP98-MLXIP-20-GOGR 20 (40 μL) 200 μL
NUP98-MLXIP-20-GOAQ 20 (40 μL) 200 μL
NUP98-MLXIP-20-GRRE 20 (40 μL) 200 μL
NUP98-MLXIP-20-GROR 20 (40 μL) 200 μL
NUP98-MLXIP-20-GRGO 20 (40 μL) 200 μL
NUP98-MLXIP-20-GRGR 20 (40 μL) 200 μL
NUP98-MLXIP-20-GRAQ 20 (40 μL) 200 μL
NUP98-MLXIP-20-AQRE 20 (40 μL) 200 μL
NUP98-MLXIP-20-AQOR 20 (40 μL) 200 μL
NUP98-MLXIP-20-AQGO 20 (40 μL) 200 μL
NUP98-MLXIP-20-AQGR 20 (40 μL) 200 μL
NUP98-MLXIP-20-AQAQ 20 (40 μL) 200 μL

NUP98 Gene Summary

Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]

Gene Name: Nucleoporin 98

Chromosome: CHR11: 3696239 -3819022

Locus: 11p15.4

MLXIP Gene Summary

This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]

Gene Name: MLX Interacting Protein

Chromosome: CHR12: 122516759 -122628967

Locus: 12q24.31

Gene Diseases

The NUP98 MLXIP Fusion has been associated with the following diseases:

Disease Name
Uterine Corpus Endometrial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.