NXN-WRAP53 Fusion FISH Probe
The NXN-WRAP53 Fusion FISH Probe is used to confirm a fusion of the NXN and WRAP53 genes. The fusion of the NXN and WRAP53 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NXN-WRAP53-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-RERE | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-REOR | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-REGO | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-REGR | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-REAQ | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-ORRE | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-OROR | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-ORGO | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-ORAQ | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-GORE | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-GOOR | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-GOGO | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-GOGR | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-GOAQ | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-GRRE | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-GROR | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-GRGO | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-GRGR | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-GRAQ | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-AQRE | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-AQOR | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-AQGO | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-AQGR | 20 (40 μL) | 200 μL |
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| NXN-WRAP53-20-AQAQ | 20 (40 μL) | 200 μL |
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WRAP53 Gene Summary
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Name: WD Repeat Containing Antisense To TP53
Chromosome: CHR17: 7589388 -7606820
Locus: 17p13.1
NXN Gene Summary
This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]
Gene Name: Nucleoredoxin
Chromosome: CHR17: 702552 -882998
Locus: 17p13.3
Gene Diseases
The NXN WRAP53 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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